Turmeric root has been used for at least 4,000 years in India and its Asiatic neighbours. It is one of their most highly reputed herbs and also a spice found in almost all Indian cuisine. It is worthy to note that in India, many common diseases occur remarkably less frequently, including tumour diseases. Relative to this it is even more surprising as their consumption levels of sugar, refined carbohydrates and milk are high, factors which are known to increase the risk of these illnesses in the West. High turmeric consumption is traditionally thought to explain the lower occurrence of diseases. As a consequence, this plant attracted significant scientific attention and study and analysis. The outcome of these investigations suggested that it was very effective in in vitro and animal studies relative to cases of cancer, arthritis and nervous system conditions and other health problems.
Hitherto, studies performed on people (human clinical studies) only found it useful in cases of intestinal conditions, because of the traditional limitations enacted by orally administered turmeric and curcumin (the main active substance). These substances could not pass from the intestinal system to the blood, through ingestion. Whereas, to be effective in the body as a whole, the active substance has to successfully cross the so-called blood-brain barrier. Therefore it has to get into the bloodstream, to be effective in the digestive system, the brain, the nervous system etc. Historic observations suggested that to achieve absorption into the bloodstream, turmeric extracts with high curcumin content (95%) were administered in the form of injections, thus entering the blood circulation system directly. Modern innovation has furnished an increasing number of solutions to deliver orally taken curcumin into the bloodstream efficiently. Many of the products were found effective in a myriad of conditions (Arthritis, Alzheimer’s, Depressions, Digestive and Intestinal disorders etc.). But! In the main, these proffered solutions were compromised by harmful side effects. A consequence of the inclusion of differing absorption additives (e.g. polysorbate emulsions or soy proteins). Many of which increase the permeability of the intestinal walls, which is not good.
Through the implementation of modern technologies and methodologies, the oral delivery system has greatly benefitted over the years from research, discovery and the development of natural and healthy solutions. These natural remedies are carefully selected and utilised in our product. This expertise and finesse are what makes our product unique.
The active substances of turmeric
The better researched active substances are Curcuminoids (of which there are 3 types). The spice itself contains approx. 3% of these. The majority of research studies related to turmeric are focusing on curcuminoids (and among these, primarily on curcumin). It also has to be mentioned that turmeric root contains -1-2% of essential oils, some constituents of which - called turmerones - have strong anti-inflammatory and antioxidant effects. Besides having similar and synergistic effects with curcuminoids, they significantly increase the absorption rate of orally administered curcuminoids into the bloodstream. Conventional turmeric extracts, standardized for curcumin, do not contain turmerones present in essential oils.
The issue of absorption of Turmeric and its practical implications
The following natural and healthy techniques are available to improve the absorption rate without adverse effects:
A pungent active ingredient of peppers and chilli, piperine increases the blood supply of the intestine system, which in itself helps absorption; on the other hand, it decreases the activity of the liver enzyme P450, which would break down curcumin into ineffective degradation products. In a human clinical trial, the group that took curcumin together with a black pepper extract with high piperine content - patented under the name of BioPerine® - had 20 times higher blood curcumin levels compared to the other group taking the same amount of curcumin without BioPerine®. In addition, BioPerine® helps curcumin to cross the blood-brain barrier, thus it can perform its beneficial effects on the brain and the nervous system. Similarly to piperine, gingerols extracted from ginger increase the bioavailability of curcumin through similar mechanisms, although this was not yet confirmed in clinical trials, only in animal studies. Meanwhile, it was clinically confirmed that ginger extracts standardized for gingerols have a strong anti-inflammatory effect, with a similar mechanism to that of curcumin. Historic research discovered, that in the ancient Indian medicine system, Ayurveda, turmeric was combined over millennia with a preparation that helped absorption, called “trikatu”, which contains black pepper, long pepper and ginger, that is, piperine and gingerol.
A better and more most natural method has been developed recently:
Curcuminoids are mixed with a special version (high aromatic turmerone content, obtained without heat or chemical treatment) of the previously mentioned turmeric essential oil, then this special essential oil - curcuminoid complex is micronized, thus resulting in the production of a full-spectrum extract. This was patented under the names BioPerine® and BCM-95®. By comparing this with the piperine-lecithine-curcumin complex (the method used previously to promote absorption), it was determined that employing this method generated a 6-fold plus increase in the amount of curcumin entering the bloodstream of the study participants. Allied to this; is the benefit of the antioxidant and anti-inflammatory effects of the turmerone constituents of turmeric essential oils.
The extraordinary effects of BioCurcumin® Turmeric have recently been proved in patients with Alzheimer’s disease, Rheumatoid Arthritis and Osteoarthritis. This demonstrates that the substance really entered the bloodstream (and thus, the joints as well), moreover, relative to the Alzheimer’s disease outcome it must have crossed the blood-brain barrier to enter the brain (Alzheimer).
1g of BioCurcumin® increases blood curcumin levels more than a 12g of a traditional extract with high (95%) curcuminoid content, complemented with a high-fat diet with a slow transit time that is favourable in terms of absorption.
Effects already confirmed by human clinical trials
Reducing and removing arthritic problems
A study in 2012 targeted a group of patients suffering from moderate rheumatic pain were divided into two trials. In group one each received 2×50mg strong anti-inflammatory and analgesic medication containing the active substance diclofenac. Group two of the patients received 2×500mg BioCurcumin®. Patients who received BioCurcumin® experienced more significant improvement in their status and more pain relief compared to the group taking the strong medication.
It was noteworthy to observe that while the medication has a direct pain reducing the effect, the pain-reducing effect of BioCurcumin® can only be explained by an improvement in the cause of the problem. In another study in 2011, the efficacy of a preparation comprising BioCurcumin® and BosPure® incense extract was confirmed in patients suffering from osteoarthritis pain.
In a study in 2014, a group of patients with depression took 500mg Bio-Curcumin® daily for 6 weeks, which resulted in a 62.5% improvement measured on the Hamilton-scale. This was similar to the improvement achieved in the patient group taking antidepressants. The patient group taking both Bio-Curcumin® and antidepressants showed, even more, 77.8% improvement.
Managing Alzheimer’s disease
In a study in 2008, daily 1g Bio-Curcumin® improved the state of patients with Alzheimer’s disease. It significantly decreased the amount of beta-amyloid plaques in the brain, which cause the disease; therefore it was observed that not only could it relieve the symptoms but might also reverse them.
Research studies concentrating on Bio-Curcumin® continue... It has been proved to be effective in in vitro and animal studies against urogenital diseases and breast and prostate cancer, and also that it helps the detoxifying function of the liver.
Other effects of curcumin, confirmed in human studies
It greatly reduces general inflammation in the body, the level of CRP, triglycerides and cholesterol, pain, lipid peroxidation, blood pressure, oedema, depression, the risk of a number of tumour diseases, and the occurrence and symptoms of gastric or colorectal ulcers. In addition, it is a very strong antioxidant, and it also increases insulin sensitivity.
It has to be noted that, Bio-Curcumin® in itself elevates blood curcumin levels highly effectively, and it can cross the blood-brain barrier as the above-mentioned studies demonstrate clearly. We further increased its effectivity, as we have combined it with other methods to help absorption. As an extra to Bio-Curcumin®, our product is infused with large amounts of turmeric essential oil, ginger extract, ginger essential oil and BioPerine® welcome additions. We are not aware of any other product that combines all of the available methods to promote the absorption of turmeric.
Made in the EU
KEEP OUT OF REACH OF CHILDREN. DO NOT EXCEED RECOMMENDED DOSE.
If you are undergoing treatment for a medical condition or if you are pregnant or lactating, please consult your medical practitioner before introducing supplementary foods to your normal routine. The dietary supplement should not be used as a substitute for a varied and balanced diet or a healthy lifestyle. Store tightly closed in a cool and dry place.
- United States Department of Agriculture: „Sugar: World Markets and Trade” Foreign Agricultural Service, November 2013
- The Food and Agriculture Organization of the United Nations (FAO): Milk Production in India and the United States from 2005 to 2011; FAO-STAT. June 4, 2013. (http://faostat.fao.org)
- V. Mohan, G. Radhika, P. Vijayalakshmi, V. Sudha: Can the diabetes/cardiovascular disease epidemic in India be explained, at least in part, by excess refined grain (rice) intake? Indian J Med Res 131, March 2010, pp 369-372
- Bengmark, S.: Plant-derived Health-Effects of Turmeric and Curcumenoids Kuwait Medical Journal 2006, 38 (4): 267-275
- Shiyou Li, Wei Yuan, Guangrui Deng, Ping Wang, Peiying Yang, Bharat B. Aggarwal: Chemical Composition and Product Quality Control of Turmeric (Curcuma longa L.) Pharmaceutical Crops, 2011, 2, 28-54
- Srinivas L, Shalini VK, ShylajaM. Turmerin: a water soluble antioxidant peptide from turmeric [Curcuma Longa]. Archem Biochem Biophys. 1992 Feb 1; 292 (2): 617-23.
- Reji Kizhakkedath: Clinical evaluation of a formulation containing Curcuma longa and Boswellia serrata extracts in the management of knee osteoarthritis. Molecular Medicine Reports, DOI: 10.3892/mmr.2013.1661
- Chandran B, Goel A. A Randomized, Pilot Study to Assess the Efficacy and Safety of Curcumin in Patients with Active Rheumatoid Arthritis. Phytother Res. March 9, 2012 doi: 10.1002/ptr.4639
- Antony B, Kizhakedath R, Benny M, Kuruvilla BT. Clinical Evaluation of a herbal product (Rhulief™) in the management of knee osteoarthritis. Abstract 316. Osteoarthritis Cartilage. 2011;19(S1):S145-S146.
- Baum L et al. Six-Month Randomized Placebo-Controlled, Double-Blind, Pilot Clinical Trial of Curcumin in Patients with Alzheimer’s Disease. Journal of Clinical Psychopharmacology. Vol 28, Number 1, Feb 2008 pg 110-114
- Belcaro et al: Efficacy and safety of Meriva®, a curcumin-phosphatidylcholine complex, during extended administration in osteoarthritis patients. Altern Med Rev. 2010 Dec;15(4):337-44.
- Garcea et al: Consumption of the putative chemopreventive agent curcumin by cancer patients: assessment of curcumin levels in the colorectum and their pharmacodynamic consequences. Cancer Epidemiol Biomarkers Prev. 2005 Jan;14(1):120-5.
- Preetha Anand, Ajaikumar B. Kunnumakkara, Robert A. Newman, and Bharat B. Aggarwal: Bioavailability of Curcumin: Problems and Promises Mol. Pharmaceutics, 2007, 4 (6), 807-818• DOI: 10.1021/mp700113r
- Shaiju et al: Pharmacokinetics of Curcumin Conjugate Metabolites in Healthy Human Subjects Cancer Epidemiol Biomarkers Prev June 2008 17; 1411
- Singh et al: Piperine : A Bioenhancer International Journal of Pharmacy Research and Technology 2011 1(1) 01-05
- Unibar Corporation: CurQnetic™ Bioavailability Studies (http://unibarcorp.com/research)
- Khajuria és et al (2003) In-house study for a patent work
- Wigler I, Grotto I, Caspi D, Yaron M: The effects of Zintona EC (a ginger extract) on symptomatic gonarthritis. Osteoarth Cartilage. 2003 Nov;11(11):783-9.
- Grzanna R, Lindmark L, Frondoza CG: Ginger--an herbal medicinal product with broad anti-inflammatory actions. J Med Food. 2005 Summer;8(2):125-32.
- Antony et al: A Pilot Cross-Over Study to Evaluate Human Oral Bioavailability of BCM-95®CG (Biocurcumax™), A Novel Bioenhanced Preparation of Curcumin Indian J Pharm Sci. 2008 Jul-Aug; 70(4): 445–449.
- Grant KL, Schneider CD. Turmeric. Am J Health-Syst Pharm 2000; 57:1121-1122.